Saturday's game at Rodney Parade pits two teams against each other who are hoping a managerial change will ignite their seasons.
Colchester tomorrow will be new County gaffer Graham Coughlan's first game in charge of the Exiles following his arrival on Thursday.
United have also made a change in the dugout with Matt Bloomfield taking control of the Essex-based club on September 30 but he's so far only earned three points from a possible nine in the league.
A 2-1 win over Harrogate Town was sandwiched in-betweeen defeats to AFC Wimbledon and Swindon Town, 2-1 and 1-0 respectively.
County also need an uplift in the league after a 2-1 defeat at Crawley last weekend that had Sporting Director Darren Kelly in interim charge but confidence will be up after the midweek 2-1 win over Southampton U21s in the EFL Trophy.
Thierry Nevers came off injured after half an hour in that game so County will be hoping that's not too serious but that is County's only ongoing injury concern currently.
Bloomfield will be hoping to have Kwesi Appiah and Matt Longstaff back after both missed their EFL Trophy game in midweek and the same applies to Bez Lubala and Ossama Ashley.
Of Colchester's three league games under Bloomfield, two have been away from home and both were defeats with the one win coming at Layer Road.